ceesdekker.net Fundamentals Explained
ceesdekker.net Fundamentals Explained
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‘Sure, that may be about proper. I seek for a physical comprehension of Organic techniques in a bottom-up way. I feel you could potentially distinguish three traces of investigate in my group in the intervening time. The very first worries chromosome composition: how do you get yourself a metre-very long DNA polymer folded and organised in such a microscopic cell? We've got made visualisation methods that let us to check how, for example, SMC proteins loop DNA (video clip on Youtube) in an effort to Establish up chromosomes.
It had been only within the nineties although, when nanotechnology experienced Superior to the degree wherever single molecules may be manipulated, that the first experimental units commenced to appear.
Again in 1991, Sumio Iijima of your NEC Company experienced claimed the synthesis of carbon nanotubes. Band composition calculations suggested that these nanotubes could show metallic band conduction. This would be a significant advantage over the conducting polymers we had explored, which were, in fact, disordered semiconductors offering merely variable-range hopping conductivity.
Sadly, For some time right after Iijima’s report, the creation of thoroughly clean nanotubes was cumbersome. In 1996, having said that, the group of Richard Smalley at Rice College managed to produce solitary-walled carbon nanotubes at superior yield. Soon after, I contacted Smalley, and we chose to sign up for forces to measure the transport via a single carbon nanotube.
We create point-of-treatment diagnostics examination of neglected tropical ailments within resource-confined options, depending on Crspr/Cas9 detecting of pathogen’s DNA in physique fluids.
Illustration (3) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in gray, the rim from the pore is highlighted in red, and a 3D rendering of your motion of the DNA rod is exhibited.
Considering that 2000 he moved to single-molecule biophysics and nanobiology, with research from DNA supercoiling experiments of nucleosomes and DNA repair service proteins to DNA translocation by way of nanopores. Just lately his study has centered on finding out cell division with microbes on chip, when his final interest is during the route of acknowledging synthetic cells.
Atomic pressure microscopy reveals that vaccinia topoisomerase IB generates filaments on DNA within a cooperative vogue
Comprehension elementary processes regulating the spatial and dynamic organisation on the DNA in Stay cells.
Dekker started off his exploration on solitary carbon nanotubes in 1993 when he arrange a new line of exploration to study electrical transport by means of single natural and organic molecules amongst nanoelectrodes. In 1996 a breakthrough was recognized with carbon nanotubes. This was accomplished inside of a collaboration While using the team of Nobel laureate Richard Smalley. STM and nanolithography tactics were being accustomed to exhibit that these nanotubes are quantum wires at the single-molecule amount, with remarkable Bodily properties.
[fourteen] In 2005 Dekker became involved with Netherlands-wide discussions about Clever Design and style, a motion that he has because Plainly distanced himself from. Dekker advocates that science and religion will not be in opposition but can be harmonized.
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij met enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart structure in 2005. (nl)